Resveratrol is found in plants where it is designed to help increase the life span of the plant by making them resistant to disease, injury, and stressors. In the human body, resveratrol is known for a host of anti-aging protective benefits including:
- Combating damaging free radicals in the body
- Reducing inflammation
- Has antioxidant and antimicrobial properties
- Has an especially potent neuroprotective effect
- Improves mitochondrial health by promoting autophagy (self-cleaning), see Main Article
- Protecting against depression
- Improving brain blood flow and suppressing brain inflammation
- May be able to make cancerous tumors more vulnerable to conventional cancer treatments (i.e. chemotherapy and radiation) and reduce side effects of treatment
Resveratrol is a polyphenolic compound with antioxidant activity found in grapes, wine, raspberries, blueberries, cranberries, mulberries, pomegranate, ginger, and organic dark chocolate or raw cacao. The typical 5-oz glass of red wines contains about 0.5 mg trans-resveratrol. It would take approximately 500 glasses to obtain what is found in one capsule of Resveragen. Japanese Knotweed (Polygonum cuspidatum) root extract has been concentrated and standardized to 50% trans-resveratrol. Each capsule provides 250 mg elemental trans-resveratrol.
To clarify, drinking wine is not the way to ensure optimal levels! Unfortunately, the alcohol counteracts the resveratrol benefit by elevating insulin levels and having neurotoxic effects. While muscadine grapes are known for high levels of resveratrol, most of which resides in the skin and seeds, this is also a high sugar source, detrimental to your glucose levels, especially if you are insulin resistant. In addition to the foods listed at the beginning of the article, you may want to look into itadori tea, also made from the Japanese knotweed. Optimal levels may best be accomplished through supplementation and should be discussed with your functional medicine provider.
 Klaire Labs, 2019 Practitioner Product Catalog, Resveragen, pg. 82.